ML-406 Datasheet DC Chemicals
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Cat.No DC20456
Name ML-406

Chemical Properties

CAS 774589-47-8
Formula C20H20N2O4
MW 352.38
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：774589-47-8
Product Name：1-(4-(4-(Benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethanone
Synonyms：ML-406;ML 406;ML406
EINECS:
Molecular Formula：C20H20N2O4
Molecular Weight：352.39
Target: IC50 30 nM (BioA)[1]
In Vivo
In Vitro ML406 inhibits WT Mycobacterium tuberculosis (Mtb) (H37Rv) growth inhibition with the IC50 of 3.2 μM. BioA is an enzyme involved in biotin biosynthesis in Mtb that may serve as lead compounds for drug development for tuberculosis (TB)[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Dominick Casalena, et al. Discovery of small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition. January 16, 2015.
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