ACT-389949 Datasheet DC Chemicals

Description	ACT-389949 is a novel potent and selective formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX) agonist with EC50 of 3 nM, shows potential for the treatment of inflammatory disorders..
Cat.No	DC20639
Name	ACT-389949

Chemical Properties

CAS	1258417-54-7
Formula	C20H18F2N6O3
MW	428.4
Storage	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

References

[1]. Stalder AK,et al. Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2017 Mar;83(3):476-486. [2]. Lind S, et al. Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949. Biochem Pharmacol. 2019 Aug;166:163-173.

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