ASTX660(Tolinapant） Datasheet DC Chemicals
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Cat.No DC20695
Name ASTX660(Tolinapant）

Chemical Properties

CAS 1799328-86-1
Formula C30H42FN5O3
MW 539.684590816498
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1799328-86-1
Product Name：1-(6-(4-fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one
Synonyms：ASTX 660;ASTX-660
EINECS:
Molecular Formula：C30H42FN5O3
Molecular Weight：539.684590816498
Target:
In Vivo In HCC1806 xenografts in mice, ASTX660 (daily oral treatment) causes moderate tumor growth inhibition but not regression[1].
In Vitro ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP, currently being investigated in a single-agent Phase 1/2 clinical trial in patients with advanced solid tumors and lymphomas. Twenty-one triple-negative breast cancer (TNBC) cell lines are treated with ASTX660 in vitro and it is found that 43% are sensitive to ASTX660[1].
Kinase Assay
Cell Assay
Animal Administration

References

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