AZD 4205 Datasheet DC Chemicals

Description	AZD 4205 (AZD4205) is a potent, selective JAK1 inhibitor IC50 of 73 nM and Ki of 2.8 nM, shows high selectivity against JAK2 and JAK3 with IC50 of 13,233 nM and >30,000 nM respectively; shows potent inhibition of p-STAT3 in a cell based assay of JAK1 activity with an IC50 of 128 nM and excellent selectivity across the kinome; reduces residual disease and prolongs the benefit of Osimertinib in lung cancer patients with EGFR activating mutations both in vitro and in vivo.
Cat.No	DC20726
Name	AZD 4205

Chemical Properties

CAS	2091134-68-6
Formula	C25H31N9O2
MW	521.601
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Annika Birgitta Margareta ÅSTRAND, et al. Compounds and methods for inhibiting jak

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