AZD 4205 Datasheet DC Chemicals
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Cat.No DC20726
Name AZD 4205

Chemical Properties

CAS 2091134-68-6
Formula C25H31N9O2
MW 521.601
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target: JAK1:73 nM (IC50)
In Vivo AZD-4205 (12.5 mg/kg BID (twice daily), 25 m/kg BID or 50 mg/kg BID, p.o.) alone has increasing antitumor effects, and ehances the antitumor activity of osimertinib, compared to treatment with osimertinib alone in mice bearing NCI-H1975 cells[1].
In Vitro AZD-4205 (Example 32) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2, and shows little inhibition on JAK3 (IC50, >14.7, >30 μM, respectively). AZD-4205 significantly inhibits STAT3 phosphorylation in NCI-H 1975 cells with an IC50 of 161 nM[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Annika Birgitta Margareta ÅSTRAND, et al. Compounds and methods for inhibiting jak
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