Peptide P60 Datasheet DC Chemicals

Description	Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3; inhibits murine and human-derived Treg and improves effector T cell stimulation, overcomes the inhibitory effect of FOXP3 on the activity of the transcription factors NF-κB and NFAT, inhibits upregulation of mRNA for Foxp3 and IL-10 on effector T cells and enhances mRNA for IFN-γ after anti-CD3 stimulation; induces a scurfy-like disease in newborn mice, improves vaccine efficacy in mice model of CT26 tumor and HCV infection.
Cat.No	DC21021
Name	Peptide P60

Chemical Properties

CAS	1319725-20-6
Formula	C95H132N24O20S2
MW	1994.34
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

1. Casares N, et al. J Immunol. 2010 Nov 1;185(9):5150-9.

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