IRE1 RNase inhibitor 8866(MKC8866) Datasheet DC Chemicals

Description	IRE1 RNase inhibitor 8866 (MKC8866, MKC-8866) is a spectific small molecule inhibitor of mammalian IRE1 RNase activity, prevents the recombinant IRE1 protein from cleaving the synthetic XBP1 RNA probe.
Cat.No	DC21308
Name	IRE1 RNase inhibitor 8866(MKC8866)

Chemical Properties

CAS	1338934-59-0
Formula	C18H19NO7
MW	361.35
Storage	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

References

[1]. Zeng, Qingping, et al. IRE-1α inhibitors. US9867803. [2]. Logue SE, et al. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun. 2018 Aug 15;9(1):3267.

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