ML349 Datasheet DC Chemicals
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Cat.No DC21321
Name ML349

Chemical Properties

CAS 890819-86-0
Formula C23H22N2O4S2
MW 454.56
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：890819-86-0
Product Name：(5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone
Synonyms：ML-349;ML 349
EINEC:
Molecular Formula：C23H22N2O4S2
Molecular Weight：454.56
Target:
In Vivo
In Vitro ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively[1]. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley[2]. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells[3].
Kinase Assay
Cell Assay
Animal Administration

References

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