Gliocidin Datasheet DC Chemicals

Description	Gliocidin is a prodrug that is anabolized into its tumoricidal metabolite, gliocidin–adenine dinucleotide (GAD). Gliocidin kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2). Gliocidin penetrates the blood–brain barrier and extends the survival of mice with orthotopic glioblastoma.
Cat.No	DC21715
Name	Gliocidin

Chemical Properties

CAS	62289-81-0
Formula	C10H8N2OS
MW	204.247
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

Nature-20 November 2024 Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma

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