BTZO-1 (0-330 nM; 24 hours) dose-dependently suppressed serum deprivation-induced cardiomyocyte death; the minimum effective concentration (MEC1.5), the concentration of a sample necessary to give a 50% increase in cell viability, is 16 nM[1]. BTZO-1 (0.37 μM; 21 hours) upregulates mRNA protein levels of GST Ya and HO-1 in cardiomyocytes[1]. Cell Viability Assay[1] Cell Line: Primary Neonatal Rat Cardiomyocytes Concentration: 0-330 nM Incubation Time: 24 hours Result: Suppressed serum deprivation or DOX-induced cell death.
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Kimura H, et al. BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression.Chem Biol. 2010 Dec 22;17(12):1282-94.
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