MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM); demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling.
Cat.No
DC22145
Name
MF-766
Chemical Properties
CAS
1050656-06-8
Formula
C27H21F3N2O3
MW
478.471
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
References 1. Colucci J, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3760-3. View Related Products by Target Prostaglandin Receptor
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