Chemical Properties
| CAS |
2231744-29-7 |
 |
| Formula |
C41H41N9O8 |
| MW |
787.81974864006 |
| Storage |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Biological activity
| Description |
CAS NO.：2231744-29-7
Product Name：2-[2-[2-[4-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethoxy]ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]acetamide
Synonyms：2-[2-[2-[4-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethoxy]ethoxy]-N
EINEC:
Molecular Formula：C41H41N9O8
Molecular Weight：787.81974864006 |
| Target: |
DC50: 1 nM (BTK)[1]. |
| In Vivo |
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| In Vitro |
MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1]. |
| Kinase Assay |
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| Cell Assay |
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| Animal Administration |
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References
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[1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575. |
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