Chemical Properties
| CAS |
883050-24-6 |
 |
| Formula |
C16H13FN2O2S |
| MW |
316.35 |
| Storage |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Biological activity
| Description |
CAS NO.：883050-24-6
Product Name：4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
Synonyms：CCG50014;CCG 50014
EINEC:
Molecular Formula：C16H13FN2O2S
Molecular Weight：316.35 |
| Target: |
RGS4:30 nM (IC50)
RGS8:11 μM (IC50)
RGS16:3.5 μM (IC50)
RGS19:0.12 μM (IC50) |
| In Vivo |
CCG50014 (10, 30, or 100 nM) attenuates the nociceptive responses during the late phase in a dose-dependent manner[2]. |
| In Vitro |
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| Kinase Assay |
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| Cell Assay |
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| Animal Administration |
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References
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[1]. Blazer LL, et al. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry. 2011 Apr 19;50(15):3181-92.
[2]. Yoon SY, et al. Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test. Anesth Analg. 2015 Mar;120(3):671-7. |
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