Reconstitution with naïve CD4+CD45RBhi cells isolated from spleen and lymph nodes of C57BL/6 mice, Rag1-/- mice begin losing weight after 4 week. MS402 (10 mg/kg; intraperitoneally twice a week for 3 weeks) shows much less weight loss[1]. Animal Model: C57BL/6 mice, Rag1-/- mice with T-cell transfer-induced colitis model[1] Dosage: 10 mg/kg Administration: Intraperitoneally twice a week for 3 weeks Result: Showed much less weight loss.
In Vitro
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Cheung K, et al. BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957.
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