A potent PI3K inhibitor with IC50 3 nM, does not inhibit PI4K activity.
Cat.No
DC25092
Name
Wortmannin
Chemical Properties
CAS
19545-26-7
Formula
C23H24O8
MW
428.4319
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
[1]. Yano H, et al. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem, 1993, 268(34), 25846-25856.
[2]. Sarkaria JN, et al. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res, 1998, 58(19), 4375-4382.
[3]. Nakanishi S, et al. Wortmannin, a microbial product inhibitor of myosin light chain kinase. J Biol Chem, 1992, 267(4), 2157-2163.
[4]. Ng SS, et al. Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin Cancer Res, 2001, 7(10), 3269-3275.
[5]. Teranishi F, et al. Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo. Cancer Sci. 2009 Apr;100(4):770-7.
[6]. Liu Y, et al. Polo-like kinases inhibited by Wortmannin. Labeling site and downstream effects. J Biol Chem. 2007 Jan 26;282(4):2505-11.
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