2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：92169-45-4 Product Name：L-Leucine, L-lysyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl- Synonyms：Lys-Ile-Pro-Tyr-Ile-Leu;Neuromedin N (rat, mouse, porcine, canine) EINEC: Molecular Formula：C38H63N7O8 Molecular Weight：745.9489
Target:
Dopamine D2 receptor[1].
In Vivo
In Vitro
Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Li XM, et al. Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci Lett. 1993 Jun 11;155(2):121-4.
[2]. Checler F, et al. Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur J Pharmacol. 1986 Jul 31;126(3):239-44.
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