FB23-2(FTO Demethylase inhibitor FB23-2) Datasheet DC Chemicals
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Cat.No DC23119
Name FB23-2(FTO Demethylase inhibitor FB23-2)

Chemical Properties

CAS 2243736-45-8
Formula C18H15CL2N3O3
MW 392.236
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target: IC50: 2.6 μM (FTO)[1]
In Vivo FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice[1].
In Vitro FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells[1]. FB23 inhibits the proliferation of NB4 and MONOMAC6 cells, with IC50 values of 0.8 μM and 1.5 μM[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Huang Y, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35(4):677-691.e10.
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