SZL P1-41 Datasheet DC Chemicals
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Cat.No DC23210
Name SZL P1-41

Chemical Properties

CAS 222716-34-9
Formula C24H24N2O3S
MW 420.524
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：222716-34-9
Product Name：4H-1-Benzopyran-4-one, 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-
Synonyms：
EINEC:
Molecular Formula：C24H24N2O3S
Molecular Weight：420.524
Target:
In Vivo SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.
In Vitro SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. SZL P1-41 prevent Skp2-Skp1 interactions and Skp2 SCF E3 ligase activity. The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis.
Kinase Assay
Cell Assay
Animal Administration

References

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