Chemical Properties
| CAS |
2166387-64-8 |
 |
| Formula |
C26H32CLN7O5 |
| MW |
558.0292 |
| Storage |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Biological activity
| Description |
CAS NO.：2166387-64-8
Product Name：1-[5-Chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide
Synonyms：BI-3812;1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide;BCP31903;s8735;SB40386;BI 3812; BI3812;1-[5-Chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidi
EINEC:
Molecular Formula：C26H32CLN7O5
Molecular Weight：558.0292 |
| Target: |
IC50: ≤3 nM (BCL6 BTB)[1] |
| In Vivo |
BI-3812 is a BCL6 inhibitor, with an IC50 of ≤3 nM. BI-3812 shows an IC50 of 40 nM for the cellular BCL6[1]. |
| In Vitro |
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| Kinase Assay |
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| Cell Assay |
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| Animal Administration |
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References
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[1]. Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20(12):2860-2875. |
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