NI-42 Datasheet DC Chemicals
Target Home > Products > Featured products
Cat.No DC23371
Name NI-42

Chemical Properties

CAS 1884640-99-6
Formula C18H15N3O3S
MW 353.396
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target: BRPF1:7.9 nM (IC50) BRPF2:48 nM (IC50) BRPF3:260 nM (IC50) BRPF1:40 nM (Kd) BRPF2:210 nM (Kd) BRPF3:940 nM (Kd) BRD4 (BD1):4500 nM (IC50) BRD7:82 nM (IC50) BRD9:310 nM (IC50) BRD9:1130 nM (Kd)
In Vivo
In Vitro NI-42 shows IC50s of 82, 310, and 4500 nM for BRD7, BRD9, and BRD4 (BD1), respectively, and has a Kd of 1130 nM for BRD9[1].
Kinase Assay
Cell Assay
Animal Administration [1]. Igoe N, et al. Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. J Med Chem. 2017 Jan 26;60(2):668-680.

References

Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
Tel: +86-21-58447131
Fax: +86-21-61642470

Email:
sales@dcchemicals.com
order@dcchemicals.com

Website:
www.dcchemicals.com