NAB-14 Datasheet DC Chemicals

Description	NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons.
Cat.No	DC23617
Name	NAB-14

Chemical Properties

CAS	1237541-73-9
Formula	C20H21N3O3
MW	351.406
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

References 1. Swanger SA, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. View Related Products by Target iGluR

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