GSA-10 Datasheet DC Chemicals

Description	GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay.
Cat.No	DC23876
Name	GSA-10

Chemical Properties

CAS	300833-95-8
Formula	C26H30N2O5
MW	450.526807308197
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757. [2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

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