Pyr10 Datasheet DC Chemicals

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Cat.No	DC23945
Name	Pyr10

Chemical Properties

CAS	1315323-00-2
Formula	C18H13F6N3O2S
MW	449.3701
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:	IC50 value: 0.72 uM (TRPC3-ROCE), 13.08 uM (SOCE) [1] Target: TRPC3
In Vivo
In Vitro	Pyr10 displays substantial selectivity for TRPC3-mediated responses (18-fold) and the selective block of TRPC3 channels by Pyr10 barely affected mast cell activation.[1]
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012 Dec;167(8):1712-1722. [2]. Obermayer D, et al. Microwave-assisted and continuous flow multistep sy

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