ISO-1 Datasheet DC Chemicals
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Cat.No DC23954
Name ISO-1

Chemical Properties

CAS 478336-92-4
Formula C12H13NO4
MW 235.2359
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.:478336-92-4
Product Name:5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester
Synonyms:ISO 1;ISO1;MIF Antagonist
EINEC:
Molecular Formula:C12H13NO4
Molecular Weight:235.2359
Target:
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82. [2]. Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280(44):36541-4. [3]. Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3(3):135-142.
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