2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：924296-19-5 Product Name：DUBs-IN-2 Synonyms：DUBs-IN-2;DUB-IN-2;(9E)-9-ethoxyiminoindeno[1,2-b]pyrazine-2,3-dicarbonitrile EINEC: Molecular Formula：C15H9N5O Molecular Weight：275.2649
Target:
IC50: 0.28 μM (USP8)[1]
In Vivo
In Vitro
DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 μM[1].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.
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