RET-IN-1(LOXO-292) Datasheet DC Chemicals

Description	RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .
Cat.No	DC24201
Name	RET-IN-1(LOXO-292)

Chemical Properties

CAS	2222755-14-6
Formula	C29H31N9O3
MW	553.255
Storage	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

References

[1]. Steven W A, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1

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