BAY-545 Datasheet DC Chemicals
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Cat.No DC26010
Name BAY-545

Chemical Properties

CAS 1699717-32-2
Formula C18H22F3N3O4S
MW 433.4452
Storage

Biological activity

Description CAS NO.：1699717-32-2
Product Name：CID 118016229
Synonyms：3-Ethyl-6-(4-hydroxypiperidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione;ZB1532;CID 118016229;BAY-545
EINEC:
Molecular Formula：C18H22F3N3O4S
Molecular Weight：433.4452
Target: IC50: 59 nM (A2B adenosine receptor), 66 nM (Human A2B adenosine receptor), 400 nM (Mouse A2B adenosine receptor), 280 nM (Rat A2B adenosine receptor), 1300 nM (Human A1 adenosine receptor), 820 nM (Human A2A adenosine receptor), 470 nM (Mouse A2A adenosine receptor) and 750 nM (Rat A2A adenosine receptor)[1] Ki: 97 nM (A2B adenosine receptor)[1]
In Vivo
In Vitro BAY-545 is selective at A2B adenosine receptor over A1, A2A, and A3 adenosine receptor, with IC50s of 1300 nM (Human A1 adenosine receptor), 820 nM (Human A2A adenosine receptor), 470 nM (Mouse A2A adenosine receptor) and 750 nM (Rat A2A adenosine receptor)[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Härter M, et al. Novel non-xanthine antagonist of the A2B adenosine receptor: From HTS hit to lead structure. Eur J Med Chem. 2019 Feb 1;163:763-778.
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