GSK3145095 Datasheet DC Chemicals
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Cat.No DC26011
Name GSK3145095

Chemical Properties

CAS 1622849-43-7
Formula C20H17F2N5O2
MW 397.38
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1622849-43-7
Product Name：(S)-5-benzyl-N-(7,9-difluoro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-4H-1,2,4-triazole-3-carboxamide
Synonyms：GSK3145095，GSK-3145095，GSK 3145095
EINECS:
Molecular Formula：C20H17F2N5O2
Molecular Weight：397.38
Target:
In Vivo
In Vitro GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) [1].
Kinase Assay
Cell Assay
Animal Administration

References

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