CC-90009 is a cereblon modulator that selectively binds to CRBN, influencing the activity of the ubiquitin E3 ligase complex. This interaction triggers the ubiquitination and subsequent proteasome-mediated degradation of specific transcription factors, such as Ikaros (IKZF1) and Aiolos (IKZF3), which act as transcriptional repressors in T-cells. By reducing the levels of these factors, CC-90009 modulates immune system activity, potentially leading to the activation of T-lymphocytes.
Cat.No
DC28693
Name
CC-90009
Chemical Properties
CAS
1860875-51-9
Formula
C22H18CLF2N3O4
MW
461.8458
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
[1]. Ellen Filvaroff, et al. Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies. WO2017120446A1.
[2]. CC-90009
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