2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：10527-47-6 Product Name：Guanosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with adenosine Synonyms：[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] hydrogen phosphate;5'-ester with adenosine;guanosine 5'-triphosphate-5'-adenosine;Guanosine triphosphate adenosine;Guanosine5'-(tetrahydrogen triphosphate), P''®[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate; P1-Adenosine-5' P3-guanosine-5' triphosphate; Adenosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with guanosine (8CI); Guanosine triphosphate, 5'→5'-ester with adenosine
(7CI);Guanosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with adenosine (8CI);Guanosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with adenosine;Guanosine-P3-Adenosine-5',5'-Triphosphate;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(6;G3A;P1-Adenosine-5' P3-guanosine-5' triphosphate;Guanosine triphosphate, 5'>5'-ester with adenosin;Guanosine 5'-triphosphate-5'-adenosine;DTXSID401259266;Guanosine 5'-(tetrahydrogen-triphosphate), 5'-5'-ester with adenosine;Adenosine 5'-(tetrahydrogen triphosphate), 5'>5'-ester with guanosine (8CI);10527-47-6;Guanosine 5'-(tetrahydrogen triphosphate), P''>5'-ester with adenosine (9CI);Guanosine 5'-triphosphate-5'-adenosine;Guanosine 5'-triphosphate-5'-adenosine;DTXSID401259266;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate;DTXSID401259266;Guanosine 5'-(tetrahydrogen-triphosphate), 5'-5'-ester with adenosine;Q27460535;Guanosine 5'-(tetrahydrogen-triphosphate), 5'-5'-ester with adenosine;Adenosine 5'-(tetrahydrogen triphosphate), 5'>5'-ester with guanosine (8CI);CS-0179596;Adenosine 5'-(tetrahydrogen triphosphate), 5'>5'-ester with guanosine (8CI);AKOS040756445;10527-47-6;10527-47-6;Guanosine 5'-(tetrahydrogen triphosphate), P''>5'-ester with adenosine (9CI);Guanosine 5'-(tetrahydrogen triphosphate), P''>5'-ester with adenosine (9CI);Guanosine triphosphate, 5'>5'-ester with adenosine (7CI);[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-... EINEC: Molecular Formula：C20H27N10O17P3 Molecular Weight：772.4065
Target:
In Vivo
In Vitro
Guanosine 5'-triphosphate-5'-adenosine (GpppA) labeled with pyrene at the 3′‐O position of adenosine acted as an artificial substrate[1]. Fluorescently labeled Guanosine 5'-triphosphate-5'-adenosine (GpppA) and GpppG analogs as potential substrates that represent a reasonable compromise between the structural complexity and requirements of the enzyme[1].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Renata Kasprzyk, et al. Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity. Chemistry. 2020 Sep 1;26(49):11266-11275.
[2]. Dennis Reichert, et al. Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1. Chem Sci. 2021 Feb 8;12(12):4383-4388.
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