MK-8719 Datasheet DC Chemicals
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Cat.No DC60003
Name MK-8719

Chemical Properties

CAS 1382799-40-7
Formula C9H14F2N2O3S
MW 268.2788
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO Application

Biological activity

Description CAS NO.：1382799-40-7
Product Name：MK-8719
Synonyms：MK-8719; MK 8719; MK8719;
EINECS:
Molecular Formula：C9H14F2N2O3S
Molecular Weight：268.2788
Target: Ki: 7.9 nM (OGA)[1]
In Vivo MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response[1].
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29.
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