LY-3475070 Datasheet DC Chemicals
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Cat.No DC60008
Name LY-3475070

Chemical Properties

CAS 2375815-63-5
Formula C15H18N4O2
MW 286.335
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO Application

Biological activity

Description CAS NO.：2375815-63-5
Product Name：5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione
Synonyms：LY-3475070; LY 3475070; LY3475070;
EINECS:
Molecular Formula：C15H18N4O2
Molecular Weight：286.335
Target:
In Vivo
In Vitro LY-3475070 inhibits CD73 activity in human serum with an EC50 of 0.213 μM. CD73-IN-3 inhibits CD73 activity in human serum by 56.8%, 71.7% and 76.9% at 0.52 μM, 1.56 μM, 4.68 μM,respectively[1]. In Calu6 human cell assay against CD73, the IC50 for CD73-IN-3 against CD73 is 0.0073 uM[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Robert Dean Dally, et al. Cd73 inhibitors. Patent WO2019168744 A1.
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