2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：1486482-16-9 Product Name：ML251 Synonyms：2-(3,4-Dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide;ML251;2-(3,4-Dichlorophenyl)-N-(4-(N-(isoxazol-3-yl)sulfamoyl)phenyl)acetamide;2-(3,4-dichlorophenyl)-n-(4-(1,2-oxazol-3-ylsulfamoyl)phenyl)acetamide;BDBM50446100;ML251?;2-(3,4-Dichlorophenyl)-N-4-(1,2-oxazol-3-ylsulfamoyl)phenylacetamide EINEC: Molecular Formula：C17H13CL2N3O4S Molecular Weight：426.2738
Target:
IC50: 0.37 μM (T. brucei PFK)[1]. IC50: 0.13 μM (T. cruzi PFK)[1]
In Vivo
In Vitro
ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity[1]. Cell Cytotoxicity Assay[1] Cell Line: T. brucei Concentration: 0~33.3 μg/mL Incubation Time: Result: Dose-dependent reduction of cell viability.
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Brimacombe KR, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013;5(1):12-17.
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