ZINC77292789(Fmoc-Thr(galnac(Ac)3-alpha-D)-OH) Datasheet DC Chemicals
Target Home > Products > Featured products
Cat.No DC60083
Name ZINC77292789(Fmoc-Thr(galnac(Ac)3-alpha-D)-OH)

Chemical Properties

CAS 116783-35-8
Formula C33H38N2O13
MW 670.660430431366
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：116783-35-8
Product Name：Fmoc-Thr(galnac(Ac)3-alpha-D)-OH
Synonyms：Fmoc-Thr(galnac(Ac)3-alpha-D)-OH;N-Fmoc-O-beta-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-alpha-D-galactopyranosyl)-L-threonine;N-Alpha-(9-Fluoroenyloxycarbonyl)-o-(2-Acetamido-2Deoxy-3,4,6-Tri-o-Acetyl-Alpha-d-Galactopyranosyl)-l-Threonine;N-Fmoc-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-threonine;(N-alpha-Fmoc-O-beta-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-alpha-D-galactopyranosyl)-L-threonine);Fmoc-Thr(Ac₃AcNH-α-Gal)-OH;Fmoc-Thr(GalNAc(Ac)?-α-D)-OH;Fmoc-Thr(GalNAc(Ac)3-a-D)-OH;N-FMOC-O-(2-ACETAMIDO-3,4,6-TRI-O-ACETYL-2-DEOXY-A-D-GALACTOPYRANOSYL)-L-THEREONINE;FMOC-THR(GALNAC(AC)3-α-D)-OH;Fmoc-Thr[GalNAc(Ac)3-α-D]-OH;Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine;GalNAc-Thr;GALNAC L-THREONINE;FMOC-L-THR(TNAC4)-OH;FMoc-Thr-(Ac3AcNH-α-Gal)-OH;FMOC-Thr(GalNAc(Ac)3-α-D)-OH;FMoc-Thr(α-D-GalNAc(Ac)3)-OH;FMOC-THR(AC3ACNH-ALPHA-GAL)-OH;Fmoc-L-Thr(α-D-GalNAc(Ac)3)-OH;Fmoc-L-Ser(α-D-GalNAc(Ac)3)-OH
EINEC:
Molecular Formula：C33H38N2O13
Molecular Weight：670.660430431366
Target:
In Vivo
In Vitro The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Ju T, et al. The Cosmc connection to the Tn antigen in cancer. Cancer Biomark. 2014 Jan 1;14(1):63-81.
Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
Tel: +86-21-58447131
Fax: +86-21-61642470

Email:
sales@dcchemicals.com
order@dcchemicals.com

Website:
www.dcchemicals.com