ML303 Datasheet DC Chemicals
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Cat.No DC60130
Name ML303

Chemical Properties

CAS 1638211-04-7
Formula C21H16F3N3O2
MW 399.36585521698
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1638211-04-7
Product Name：2-Methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]pyridin-4-yl]phenol
Synonyms：ML303;MLS004256089;AOB4452;SMR003080964;ML303, >=98% (HPLC);2-Methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]pyridin-4-yl]phenol
EINEC:
Molecular Formula：C21H16F3N3O2
Molecular Weight：399.36585521698
Target: EC50: 0.7 μM (H1N1)[1].
In Vivo
In Vitro ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells[1]. Western Blot Analysis[1] Cell Line: MDCK cells infected with A/PR/8/34, at a MOI of 2, for 6 hours. Concentration: 20 μM. Incubation Time: 6 hours. Result: Restored IFN-β mRNA levels in MDCK cells.
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119.
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