API-1(NSC 177223) Datasheet DC Chemicals

Description	API-1 is a potent Akt inhibitor, which induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . API-1 rapidly and potently reduced the levels of Mcl-1 primarily in API-1-senstive lung cancer cell lines. Ectopic expression of Mcl-1 protected cells from induction of apoptosis by API-1.
Cat.No	DC60132
Name	API-1(NSC 177223)

Chemical Properties

CAS	36707-00-3
Formula	C13H15N5O6
MW	337.2881
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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