Soporidine binds to the AtHTL receptor and to a key Strigolactone (SL) receptor in S. hermonthica, inhibiting Striga germination in the presence of SLs. Soporidine could serve as the basis for the development of Strigolactone (SL) antagonist to combat Striga infestations. Soporidine is a potent antagonist in GR24-dependent Arabidopsis germination assay and shows no enhancement of SL signaling mutant phenotypes[1].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Duncan Holbrook-Smith, et al. Small-molecule antagonists of germination of the parasitic plant Striga hermonthica. Nat Chem Biol. 2016 Sep;12(9):724-9.
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