2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：385786-48-1 Product Name：Adaptaquin Synonyms：Adaptaquin;HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem;7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol;Hypoxia-inducible factors,peroxidation,mitochondrial,HIFs,HIF-PH,inhibit,HIF-PHD2,HIF/HIF Prolyl-Hydroxylase,Adaptaquin,Inhibitor EINEC: Molecular Formula：C21H16CLN3O2 Molecular Weight：377.823643684387
Target:
IC50: 2 μM (HIF-PHD2)[1]
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Smirnova NA, et, al. Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chem Biol. 2010 Apr 23;17(4):380-91.
[2]. Neitemeier S, et, al. Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 2016 May 5;7(5):e2214.
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