2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Biological activity
Description
CAS NO.：2089415-51-8 Product Name：PQM130 Synonyms：PQM130 EINEC: Molecular Formula：C23H27NO4 Molecular Weight：381.46
Target:
In Vivo
PQM130 (0.5-1 mg/kg, i.p., daily for 10 days) treatment after the i.c.v. AβO injection reduces oxidative damage and neuroinflammation and induces cell survival and protein synthesis through the modulation of GSK3β and extracellular signal-regulated kinases (ERK1/2) [1]. Animal Model: Adult male C57Bl/6 mice (9 weeks old, 25-30 g body weight) [1]. Dosage: 0.5 and 1.0 mg/kg. Administration: IP injection daily for 10 days. Result: Ameliorated Aβ1-42O-induced cognitive deficits in mice. Prevented Aβ1-42O-induced neuronal death in mice. Antagonized Aβ1-42O-Induced Oxidative Stress in Mice. Regulated GSK3β and ERK1/2 protein expressions in mice. Reduced Aβ1-42O-induced astrocytic activation in mice.
In Vitro
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Morroni F, et al. PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2019 Jun 12;10:658.
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