PARP10-IN-2 Datasheet DC Chemicals
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Cat.No DC65506
Name PARP10-IN-2

Chemical Properties

CAS 1042780-52-8
Formula C14H10N2O2
MW 238.241403102875
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1042780-52-8
Product Name：PARP10-IN-2
Synonyms：Benzamide, 4-(4-cyanophenoxy)-;PARP10-IN-2
EINEC:
Molecular Formula：C14H10N2O2
Molecular Weight：238.241403102875
Target: human PARP10:3.64 μM (IC50) human PARP15:11 μM (IC50) human PARP2:27 μM (IC50) human PARP12:>10 μM (IC50) human PARP16:>10 μM (IC50) human PARP1:>100 μM (IC50) human PARP3:>100 μM (IC50) human PARP4:>100 μM (IC50) human TNKS1:>100 μM (IC50) human TNKS2:>100 μM (IC50) human PARP14:>100 μM (IC50)
In Vivo
In Vitro PARP10-IN-2 (Compound 10) exhibits an IC50 of 1-2 μM in HeLa-PARP10 cells as determined by the colony formation assay (CFA) [1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948.
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