As indicated by the significant reduction in the binding offluorescent phalloidin to injected cells, it is clear that (Thymosin beta 4 can induce an extensive depolymerization of actin filaments[1]. Treatment with the exogenous Thymosin beta 4 peptide inhibits the proliferation and migration of activated HSCs and reduces liver fibrosis.
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Sanders MC, et al. Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells. Proc Natl Acad Sci U S A.
[2]. Kim J et al. Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells. Vitam Horm.
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