PROTAC BRAF-V600E degrader-1 Datasheet DC Chemicals

Description	PROTAC BRAF-V600E degrader-1 is a potent PROTAC BRAF-V600E degrader with Kd value of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS). PROTAC BRAF-V600E degrader-1 can inhibit melanoma cell growth.
Cat.No	DC65671
Name	PROTAC BRAF-V600E degrader-1

Chemical Properties

CAS	2417296-84-3
Formula	C48H54F2N10O10S
MW	1001.0652
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Han XR, et al. Discovery of Selective Small Molecule Degraders of BRAF-V600E. J Med Chem.

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