BRD4 degrader-1 Datasheet DC Chemicals

Description	BRD4 Degrader-1 (Compound ML 1-50) represents a novel class of monovalent, covalent molecular glues that selectively degrade bromodomain-containing protein 4 (BRD4) through an E3 ligase-dependent mechanism. Unlike traditional bivalent PROTACs, this compound utilizes a unique covalent binding strategy to recruit the DCAF16 E3 ubiquitin ligase, inducing potent degradation of both BRD4 long (BRD4-L) and short (BRD4-S) isoforms in cellular systems.
Cat.No	DC67342
Name	BRD4 degrader-1

Chemical Properties

CAS
Formula
MW
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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