Antitumor agent-100 hydrochloride Datasheet DC Chemicals

Description	Antitumor agent-100 (compound A6) hydrochloride is an orally bioavailable molecular glue that selectively targets the PDE3A-SLFN12 complex (IC50 = 0.3 μM). By binding to the PDE3A catalytic pocket, it stabilizes SLFN12 interaction, subsequently inhibiting protein translation and triggering apoptotic cell death. This dual mechanism underlies its potent antitumor activity.
Cat.No	DC67363
Name	Antitumor agent-100 hydrochloride

Chemical Properties

CAS	2841750-53-4
Formula	C17H15CL2N3O
MW	348.23
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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