| Description |
IAJD 294 is a single-component ionizable amphiphilic Janus dendrimer that autonomously coassembles with mRNA via simple injection into uniform monodisperse dendrimersome nanoparticles (DNPs, 85 nm diameter, PDI<0.2), eliminating complex multi-component formulations. Its optimized 3,5-benzoyl ester linkage and symmetric hydrophobic tails enable dual-organ targeting:
Spleen: 2.97 × 10⁷ RLU (50% of total activity)
Lymph nodes: 10⁶ RLU (10× higher than IAJD 87)
through partial hydrophobic interdigitation (stabilizing DNPs for enhanced lymphatic uptake) and pKa ~6.5 (facilitating endosomal escape), validating constitutional isomerism for precision delivery. |
| Cat.No |
DC67565 |
| Name |
IAJD249 |
Chemical Properties
| CAS |
3076338-32-1 |
|
| Formula |
C39H78N2O6 |
| MW |
671.05 |
| Storage |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
References
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