HDB-1 Datasheet DC Chemicals

Description	HDB-1 is a P2Y14R inhibitor for ameliorating liver fibrosis by suppressing hepatic stellate cell activation. HDB-1 demonstrates exceptional potency (IC50 = 0.026 nM) and superior metabolic stability. HDB-1 exhibited antihepatic fibrosis activity both in vivo and in vitro. Mechanistically, HDB-1 inhibits P2Y14R-mediated signaling by suppressing the PKA/Raf1/MEK/ERK cascade, thereby preventing the activation of hepatic stellate cells-the central pathological event in fibrosis development.
Cat.No	DC68175
Name	HDB-1

Chemical Properties

CAS	3021527-82-9
Formula	C18H13N3O3
MW	319.32
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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