23-hydroxy butulinic acid (23-HBA) Datasheet DC Chemicals
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Cat.No DC9802
Name 23-hydroxy butulinic acid (23-HBA)

Chemical Properties

CAS 85999-40-2
Formula C30H48O4
MW 472.6997
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：85999-40-2
Product Name：23-Hydroxybetulinic acid
Synonyms：ANEMOSAPOGININ;23-HYDROXYBETULINIC ACID;3β,23-Dihydroxylup-20(29)-en-28-oic acid;3beta,23-Dihydroxylup-20(29)-en-28-oic acid;(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS,13bR)-9-hydroxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carbox;Anemosapogenin;A,23-Dihydroxylup-20(29)-en-28-oic acid;(3β,4α)-3,23-Dihydroxylup-20(29)-en-28-oic acid;3aH-Cyclopenta[a]chrysene, lup-20(29)-en-28-oic acid deriv.;(3As,5aR,5bR,7aS,8R,11aR,11bR,13aR,13bS)-9-hydroxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-
EINEC:
Molecular Formula：C30H48O4
Molecular Weight：472.6997
Target:
In Vivo
In Vitro 23-hydroxybetulinic acid also shows different proliferation inhibitory activity against B16, HeLa, and HUVEC, with the IC50 value of 78.5, 80, and 94.8 uM, respectively. 23-hydroxybetulinic acid can promote cell cycle arrest at S phase and induce apoptosis via intrinsic pathway. 23-hydroxybetulinic acid disrupts mitochondrial membrane potential significantly (p<0.01) and selectively downregulates the levels of Bcl-2, survivin and upregulates Bax, cytochrome C, cleaved caspase-9 23-hydroxybetulinic acid can induce apoptosis in K562 cells. [1] 23-hydroxybetulinic acid enhances sensitivity of doxorubicin (DOX, ADR) on MCF-7/ADR cell lines, indicating its potential to be developed as a novel MDR modulator.[2] 23-HBA significantly improve the sensitivity of the tumor to doxorubicin. [3]
Kinase Assay
Cell Assay
Animal Administration

References

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