Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Biological activity
Description
CAS NO.：2355377-13-6 Product Name：DDO-5936 Synonyms：N-[4-[[2-(1-Pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]glycine EINEC: Molecular Formula：C25H29N5O4S Molecular Weight：495.59
Target:
Hsp90-Cdc37 PPI[1]
In Vivo
DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group[1]. DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency[1]. Animal Model: Mice[1] Dosage: 0~80 mg/kg Administration: P.o. Result: Showed a moderate effect at the high dose group.
In Vitro
DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47[1].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Wang L, et al. Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer. J Med Chem. 2020;63(3):1281-1297.
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