| Description |
Denosumab is a human IgG2 monoclonal antibody with affinity and specificity for human RANKL (receptor activator of nuclear factor kappa-B ligand). |
| Cat.No |
A008 |
| Name |
Denosumab |
Chemical Properties
| CAS |
615258-40-7 |
|
| Synonyms |
Denosumab;Denosumab (usan);AMG 162;D03684;IMMunoglobulin G2, anti-(huMan osteoclast differentiation factor) (huMan Monoclonal AMG162 heavy chain), disulfide with huMan Monoclonal AMG162 light chain, diMer;Denosumab (usan) USP/EP/BP;Research Grade Denosumab (DHA30301);Denosumab,Immunoglobulin G2,Nuclear factor-kappaB,NF-κB,Immunoglobulin G-2,RANKL,Inhibitor,Ranmark,inhibit,Cancer,Immunoglobulin G 2,Osteoporosis,Nuclear factor-κB |
| pH value |
Corresponds to reference standard： PASS |
| Non-reduced CE-SDS |
99.1% |
| SEC-HPLC |
99.9% |
| Isoelectric Point |
Corresponds to reference standard:PASS |
| Bacterial Endotoxins Test |
＜1 EU/ml |
| Residual Proteins of Host Cell |
|
| Exogenous Residual DNA |
＜1 pg/mg |
| Residual protein A |
＜1 ng/mg |
| Biological Activity |
Compared with standard, the range of biological activity is 97% |
| Osmolality |
Corresponds to reference standard: PASS |
| Peptide mapping |
Corresponds to reference standard: PASS |
| N-terminal sequence |
Corresponds to reference standard:PASS |
References
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