Chemical Properties
| CAS |
35773-42-3 |
 |
| Formula |
C20H18N2O3 |
| MW |
334.36852 |
| Storage |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Biological activity
| Description |
CAS NO.：35773-42-3
Product Name：2H-1-Benzopyran-2-one,3-(2-benzoxazolyl)-7-(diethylamino)-
Synonyms：
EINEC:
Molecular Formula：C20H18N2O3
Molecular Weight：334.36852 |
| Target: |
EGFRdel19 T790M C797S
EGFRL858R/T790M/C797S |
| In Vivo |
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| In Vitro |
EMI1 inhibits PC9 EGFR ex19del/T790M/C797S organoid growth with the EC50 of 131 nM[1]. EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1[1]. EMI1 (1 nM-100μM) strongly inhibits the viability and increase the caspase 3/7 activity of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells[1]. Cell Viability Assay[1] Cell Line: PC9 EGFR ex19del/T790M/C797S and HBE bronchial epithelial lung EGFR-WT control cells. Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM Incubation Time: 72 hours Result: Strongly inhibited the viability. |
| Kinase Assay |
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| Cell Assay |
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| Animal Administration |
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References
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[1]. Punit Saraon, et al. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat Chem Biol. 2020 May;16(5):577-586 |
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