EPZ004777 Datasheet DC Chemicals

Description	EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
Cat.No	DC5182
Name	EPZ004777

Chemical Properties

CAS	1338466-77-5
Formula	C28H41N7O4
MW	539.6696
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Daigle SR, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12;20(1):53-65. [2]. Chen L, et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22.

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